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Demerol Meperidine

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Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class.

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Description

Buy Demerol meperidrine 100mg Online

Chemically, DEMEROL meperidine  is 4-Piperidinecarboxylic acid, 1-methyl-4-phenyl-, ethyl ester, hydrochloride.

Clinical pharmacology

Meperidine hydrochloride is a narcotic analgesic with multiple actions qualitatively similar to those of morphine. Also, the most prominent of these involve the central nervous system and organs composed of smooth muscle. The principal actions of therapeutic value are analgesia and sedation.
There is some evidence that suggests that meperidine may produce less smooth muscle spasm, constipation, and depression.

Indication and Usage

Meperidine indicated for relief of moderate to severe pain.

Contraindications of Meperidine

In short , It is contraindicated in patients with hypersensitivity to meperidine.  Meanwhile, the usefulness and safety of narcotic antagonists in the treatment of these reactions is unknown.)

Warnings on use of Meperidine

Dont use Meperidine use for the treatment of chronic pain. Prolonged meperidine use may increase the risk of toxicity (e.g., seizures) from the accumulation of the meperidine metabolite, normeperidine.

Misuse, Abuse, and Diversion of Opioids

An opioid agonist of the morphine-type. Abused in a  similar manner to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing DEMEROL in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion.

equally, DEMEROL is abused by crushing, chewing, snorting, or injection. These practices will result in the uncontrolled delivery of the opioid and pose a significant risk to the abuser that could result in overdose or death

Interactions with Alcohol and Drugs of Abuse

As such, Meperidine may be expected to have additive effects when used in conjunction with alcohol. However, other opioids, or illicit drugs cause central nervous system depression.

Tolerance and Physical Dependence meperidine

However, tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia. As such, after abrupt discontinuation of a drug or upon administration of an antagonist. Therefore, physical dependence and tolerance are not unusual during chronic opioid therapy.

Adverse Reactions

To sum up, The major hazards of meperidine, as with other narcotic analgesics, are respiratory depression and, to a lesser degree, circulatory depression; respiratory arrest, shock, and cardiac arrest have occurred.

 

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