Buy Hydrocodone Online
What is hydrocodone ?
To begin, Hydrocodone is an antitussive (cough suppressant) and narcotic analgesic agent for the treatment of moderate to moderately severe pain. In addition, Studies indicate that it is as effective, or more effective.In short, codeine for cough suppression and nearly equipotent to morphine for pain relief. . With 93.7 million dispensed in 2016 and 83.6 million sold to patients in 2017.
Mechanism of action
Hydrocodone binds to the mu opioid receptor (MOR) with the highest affinity followed by the delta opioid receptors (DOR). Similarly, in the dorsal horn of the spinal cord, activation of pre-synaptic MOR on primary afferents the inhibition of calcium channel opening and increased activity of GIRK channels hyperpolarizes the neuron and prevents release of neuurotransmitters. Moreover, Post-synaptic MOR can also prevent activation of neurons by glutamate through the aforementioned mechanisms.
Indication of hydrocodone
Hydrocodone is indicated for the management of acute pain, sometimes in combination with acetaminophen or ibuprofen, as well as the symptomatic treatment of the common cold and allergic rhinitis in combination with decongestants, antihistamines, and expectorants.
Associated addiction, tolerance and dependence to hydrocodone exist just As with most opiates. To clarify, Acetaminophen co-formulation have additional liver toxicity risk at high and acute doses.
User Population of hydrocodone
Equally, hydrocodone has affected every age group due to availability. As such, little perceived safety of these products by medical prescribers. In addition, its Sometimes viewed as a “white collar” addiction, it abuse has increased among all ethnic and economic groups.
Effectively, Hydrocodone has been encountered in tablets, capsules, and liquid form. Effectively, not clandestinely produced. Moreover, Diverted pharmaceuticals are the primary source of the drug for abuse purposes. As such, Doctor shopping, altered or fraudulent prescriptions. Certainly, bogus call-in prescriptions, diversion by some physicians and pharmacists, and drug theft are also major sources of the diverted drug.
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