Description

Buy  Opana-Oxymorphone tablets Online

Oxymorphone (14-hyroxydihydromorphinone) is a potent schedule II opioid analgesic drug with an abuse liability similar to morphine and other schedule II opioids. Recently, there has been an increase in the buy and abuse of  Oxymorphone online. It is sold cheap by online sites which promise secure payment using bitcoins, cashapp, and credit cards. Such site deliver products discretely packaged at affordable prices. It was first marketed in the United States for medical use in 1959 as injectable and rectal suppository forms. Moreover, In June 2006, Food and Drug Administration (FDA) approved immediate-release (IR) and extended-release (ER) oxymorphone oral tablets under brand names Opana® and Opana ER®

Licit Uses of oxymorphone (OPANA)

Oxymorphone is indicated for the relief of moderate to severe pain. Currently marketed both as immediate release tablets containing 5 mg or 10 mg and as extended release tablets containing 5 mg, 7.5 mg, 10 mg, 15 mg, 20 mg, 30 mg, or 40 mg oxymorphone hydrochloride. It is also available as 1mg/mL injectable formulation.

Chemistry/Pharmacology

Chemically, oxymorphone is 4,5α-epoxy-3,14-dihydroxy17-methylmorphinan-6-one, commonly used as its
hydrochloride salt – a white or slightly off-white, odorless powder. Equally, which is sparingly soluble in alcohol and ether, but freely soluble in water. Pharmacological and toxic effects, abuse, and dependence liabilities of oxymorphone are essentially similar to other schedule II opioid analgesics, such as morphine and oxycodone.

Oxymorphone is a pure opioid agonist relatively selective for the mu opioid receptors. However, at higher doses, it can interact with other opioid receptors. The precise mechanism of analgesic action of oxymorphone is unknown. Similar to pure opioid agonist analgesics, with increasing doses of oxymorphone there is increasing analgesia. There is no defined maximum dose.

Effects and side effects of oxymorphone

Above all, Oxymorphone Opana is a pure opioid agonist relatively selective for the mu opioid receptors. However, at higher doses, it can interact with other opioid receptors. The precise mechanism of analgesic action of oxymorphone is unknown. Similar to pure opioid agonist analgesics, with increasing doses of oxymorphone there is increasing analgesia. As such, there is no defined maximum dose.
In addition to analgesia, other pharmacological effects of opioid agonists. That is to say, anxiolysis, euphoria, feelings of relaxation, respiratory depression, constipation, miosis (contraction of pupils), and cough suppression are common.

Risk, dependence and overdose

Use of oxymorphone, similar to other schedule II opioid analgesics, carries the risk of addiction, physical dependence and/or tolerance. Also, abrupt discontinuation after prolonged use can cause signs and symptoms of opioid withdrawal.
Acute overdose of oxymorphone, similar to other pure opioid agonists, can produce severe respiratory depression,
somnolence (drowsiness) progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted
pupils, and reduction in blood pressure and heart rate. In some cases acute overdose may result in apnea, circulatory collapse, cardiac arrest, and death. Opioid receptor antagonist such as naloxone is a specific antidote against respiratory depression resulting from overdose or unusual sensitivity to oxymorphone.

Control Status

In conclusion, Oxymorphone is controlled in schedule II of the Controlled Substances Act.

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