Buy Phentermine/Adipex 37.5mg and 30mg tablets Online
Phentermine is an oral sympathomimetic amine used as an adjunct for short-term (e.g., 8—12 weeks) treatment of exogenous obesity. However, the pharmacologic effects of phentermine are similar to amphetamines. Phentermine resin complex was approved by the FDA in 1959.. Phentermine hydrochloride was FDA approved in 1973. In the mid-90s, there was renewed interest in phentermine in combination with another anorectic, fenfluramine, for the treatment of obesity and substance abuse, however, little scientific data support this practice.
As a consequence, on July 8, 1997, the FDA issued a ‘Dear Health Care Professional’ letter warning physicians about the development of valvular heart disease and pulmonary hypertension in women receiving the combination of fenfluramine and phentermine. In May 2011, the FDA approved a phentermine hydrochloride orally disintegrating tablet (Suprenza) for the treatment of exogenous obesity.
Mechanism of Action adipex
Limited data are available in reference texts regarding the mechanism of action of this drug. Phentermine is an analog of methamphetamine. Similar to the amphetamines, phentermine increases the release of norepinephrine and dopamine from nerve terminals and inhibits their reuptake. Thus, phentermine is classified as an indirect sympathomimetic. Other effects include a weak ability to dose-dependently raise serotonin levels, although the effect on serotonin occurs is less potent than that of methamphetamine itself.3 Clinical effects include CNS stimulation and elevation of blood pressure.
Tolerance to the anorexiant effects of phentermine usually develops within a few weeks of starting therapy. The mechanism of tolerance appears to be pharmacodynamic in nature.
As a stimulant similar to some amphetamines, phentermine acts as an appetite suppressant by stimulating branches of the sympathetic nervous system. Likewise, Phertermine -indicated in the management of short term exogenous obesity. Used adjunct in a regimen of weigh reduction based on caloric restriction. Often recommended for obese patients with risk for high blood pressure, high cholesterol, or diabetes.
Phentermine contraindicated in sympathomimetic amine hypersensitivity patients.
However, the safety of phentermine when used with other anorexiant agents such as amphetamine, benzphetamine, dexfenfluramine, dextroamphetamine, diethylpropion, ephedrine, fenfluramine, and sibutramine is controversial and concurrent use should be avoided. To sum up, the role of phentermine in the production of cardiac valvulopathy when combined with dexfenfluramine, fenfluramine, or other medications for weight loss is uncertain. To note,the combined use of these agents may have the potential for additive side effects, such as hypertensive crisis or cardiac arrhythmias.
Adverse Reactions/Side Effects
However, Patients receiving phentermine reported Central nervous system adverse reactions. As such, this has included dizziness, dysphoria, euphoria, headache, insomnia. Also, overstimulation, restlessness, and tremor. Meanwhile, psychosis at recommended doses occur rarely in some patients.
Storage of adipex
Store this medication at 68°F to 77°F (20°C to 25°C) and away from heat, moisture and light. Subsequently, Keep all medicine out of the reach of children. As such, throw away any unused medicine after the beyond use date. Finally, Do not flush unused medications or pour down a sink or drain.