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What is Suboxone?
Suboxone (buprenorphine/naloxone) is a brand-name prescription drug. It’s used to treat dependence on opioid drugs. Suboxone comes as an oral film that’s placed under your tongue (sublingual) or between your gums and cheek (buccal). The film dissolves in your mouth. Suboxone contains two drugs in each film: buprenorphine and naloxone. It’s available in four strengths:
- 2 mg buprenorphine / 0.5 mg naloxone
- 4 mg buprenorphine / 1 mg naloxone
- 8 mg buprenorphine / 2 mg naloxone
- 12 mg buprenorphine / 3 mg naloxone
Studies show that Suboxone is effective for reducing opioid misuse. It’s also effective for keeping people with opioid dependence in treatment over a period of 24 weeks. (How well a drug such as Suboxone performs is partly assessed based on how long people stay in treatment).
Forms and administration
Suboxone is available as an oral film that can be used under your tongue (sublingual) or between your gums and your cheek (buccal).
Bunavail is available as a film that’s placed between your gums and your cheek (buccal).
Suboxone and other medications
Below is a list of medications that can interact with Suboxone. This list does not contain all drugs that may interact with Suboxone.
Before taking Suboxone, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
- alprazolam (Xanax)
- clonazepam (Klonopin)
- diazepam (Valium)
Drugs that block metabolism of Suboxone
Drugs that increase metabolism of Suboxone
Certain medications make an enzyme called cytochrome P450 3A4 (CYP3A4) more active and can increase how fast the body breaks down Suboxone. This can make Suboxone less effective.
Examples of these medications include:
- carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
- phenytoin (Dilantin, Phenytek)
- primidone (Mysoline)
- rifampin (Rifadin)
Suboxone and Xanax, tramadol, Adderall, Klonopin, gabapentin, anesthesia, Ambien, codeine, grapefruit also have negative interactions as such their use need to be avoided.
Suboxone may not be right for you if you have certain medical conditions. Examples of these conditions include:
- Lung disease. Suboxone can cause breathing problems. T
- Liver disease. People with liver disease might have an increased risk of withdrawal symptoms when taking Suboxone.
- Head injury. Suboxone can increase the pressure in fluid in the spinal cord and brain.
Suboxone is contraindicated in people with a known hypersensitivity to buprenorphine or naloxone.
Abuse and dependence
Suboxone is a schedule III medication that’s abused similar to other opioid medications. Long-term use of Suboxone can lead to physical and psychological dependence and drug-craving and drug-seeking behavior. In order to prevent abuse and diversion, multiple refills should not be prescribed or dispensed at the beginning of treatment.
Suboxone should be stored at room temperature, at about 77°F (25°C).