Buprenorphine/naloxone, sold under the brand name Suboxone among others, is a fixed-dose combination medication that includes buprenorphine and naloxone. In combination with counseling, it is used to treat opioid use disorder. It decreases withdrawal symptoms for about 24 hours.

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What is Suboxone?

Suboxone (buprenorphine/naloxone) is a brand-name prescription drug. Further, It’s used to treat dependence on opioid drugs. It comes as an oral film that’s placed under your tongue (sublingual) or between your gums and cheek (buccal). To begin with, the film dissolves in your mouth. It contains two drugs in each film: buprenorphine and naloxone. Interestingly, it’s available in four strengths:

  • 2 mg buprenorphine / 0.5 mg naloxone
  • 4 mg buprenorphine / 1 mg naloxone
  • 8 mg buprenorphine / 2 mg naloxone
  • 12 mg buprenorphine / 3 mg naloxone

In addition, studies show that  is effective for reducing opioid misuse. It’s also effective for keeping people with opioid dependence in treatment over a period of 24 weeks. How well a drug such as performs is partly assessed based on how long people stay in treatment.

Forms and administration

However,  is available as an oral film that can be used under your tongue (sublingual) or between your gums and your cheek (buccal).

Similarly, Bunavail is available as a film that’s placed between your gums and your cheek (buccal).

Suboxone and other medications

Below is a list of medications that can interact with Suboxone. To add, this list does not contain all drugs that may interact with Suboxone.

Before taking Suboxone, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Consequently, Also tell them about any vitamins, herbs, and supplements you use. Certainly, Sharing this information can help you avoid potential interactions.

As such, If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.


  • alprazolam (Xanax)
  • clonazepam (Klonopin)
  • diazepam (Valium)
  • midazolam

Drugs that block metabolism of Suboxone

Drugs that increase metabolism of Suboxone

Further, Certain medications make an enzyme called cytochrome P450 3A4 (CYP3A4) more active and can increase how fast the body breaks down Suboxone. This can make drug less effective.

Examples of these medications include:

  • carbamazepine (Carbatrol, Epitol, Equetro, Tegretol)
  • phenobarbital
  • phenytoin (Dilantin, Phenytek)
  • primidone (Mysoline)
  • rifampin (Rifadin)

Moreover, Xanax and Suboxone, tramadol, Adderall, Klonopin, gabapentin, anesthesia, Ambien, codeine, grapefruit also have negative interactions as such their use need to be avoided.

Suboxone warnings

In other words, Suboxone may not be right for you if you have certain medical conditions. Examples of these conditions include:

  • Lung disease. Suboxone can cause breathing problems. T
  • Liver disease. People with liver disease might have an increased risk of withdrawal symptoms when taking Suboxone.
  • Head injury.  can increase the pressure in fluid in the spinal cord and brain.


Consequently, it is contraindicated in people with a known hypersensitivity to buprenorphine or naloxone.

Abuse and dependence

Above all, long-term use can lead to physical and psychological dependence and drug-craving and drug-seeking behavior.   Likewise, in order to prevent abuse and diversion, multiple refills should not be prescribed or dispensed at the beginning of treatment.


To sum up, Suboxone should be stored at room temperature, at about 77°F (25°C).


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