Description

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Vyvanse Chemical description

Lisdexamfetamine is an amide ester conjugate.  consisting of the amino acid Llysine covalently bound to the amino group of d-amphetamine.

Chemical properties

Lisdexamfetamine dimesylate has low lipophilicity (logP-1.76) and high aqueous solubility within a biologically relevant pH range of 1-8. Therefore,  It should be stored at 25°C (77°F) with excursions permitted to 15-30°C (59-86°F).
As such, Lisdexamfetamine should be dispensed in a tight, light-resistant container.

General pharmacology of Vyvanse

Pharmacodynamics

Lisdexamfetamine is a prodrug and an inactive molecule until ingestion. After oral administration, enzyme hydrolysis following contact with red blood cells will break lisdexamfetamine into L-lysine, a naturally occurring essential amino acid and active damphetamine which is responsible for the drug’s activity. However, Gastrointestinal pH does not alter this conversion and the attachment of the L-lysine slows down the relative amount of d-amphetamine available to the blood stream and therefore the CNS.

Routes of administration and dosage

Capsule, Oral: 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 70 mg.

Pharmacokinetics

Lisdexamfetamine PO is rapidly absorbed via the gastrointestinal tract in animals. It attains a maximum plasma concentration -0.25-3 h. Studies in vitro suggest lisdexamfetamine is a substrate for the peptide transport protein PEPT1 and maybe also PEPT2.

Adverse reactions of vyvanse in humans

To begin with, When tested in subjects with a history of stimulant abuse, doses of 50-150 mg oral lisdexamfetamine dose-ependently. Equally, increased systolic and diastolic blood pressure, and pulse compared to placebo and the 150 mg dose of lisdexamfetamine produced higher changes than 40 mg d-amphetamine.

Above all, the most common adverse effects for lisdexamfetamine are insomnia (13% to 27%), decreased appetite (children and adolescents 34% to 39%; adults 27%), xerostomia (adults 26%; children and adolescents 4% to 5%), and abdominal pain (children 12%). On the other hand, adverse effects include increased blood pressure (adults 3%), increased heart rate. For example, (adults 2%), irritability (children 10%), anxiety (adults 6%), dizziness (children 5%), akathisia (adults 4%), agitation (adults 3%), emotional lability (children 3%), restlessness (adults 3%), drowsiness (children 2%), tics (children 2%), hyperhidrosis (adults 3%), skin rash (children 3%).

Dependence potential of vyvanse

To clarify, No studies  found on tolerance, sensitization, or dependence to lisdexamfetamine. However, abrupt  discontinuation following high doses or for prolonged periods may result in symptoms of withdrawal

Current and past national controls

Not control in some states but controlled in some parts of Europe and Asia

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